Supplementary Figures from Epigenomic Profiling Discovers Trans-lineage SOX2 Partnerships Driving Tumor Heterogeneity in Lung Squamous Cell Carcinoma
Year: 2023
Type: supplementary-materials
Abstract: SF1:Super-enhancer profiling identifies three subtypes of LUSC. SF2: Brn2 is expressed in a subset of human primary LUSC tumors. SF3: Brn2 and Sox2 co-localize and collaborate in the 'neural' LUSC cells. SF4: DNp63 overexpression in the 'neural' LUSC cells suppresses Brn2 expression and induces phenotypic changes. SF5: Brn2 overexpression and p63 ablation in the 'classical' LUSC cells and Brn2 ablation in the 'neural' LUSC cells. SF6: DNp63 induces a classical squamous-cell transcriptional program and G1 phase arrest in the 'neural' LK2 cells. SF7: DNp63 suppresses the 'neural' lineage program and induces the classical squamous-cell transcriptional program. SF8: DNp63 alters ErbB family signaling in the 'neural' LK2 cells.
Language: English
Topic: Lung Cancer Research Studies
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361898400