Supplementary Data from Zebrafish MITF-Low Melanoma Subtype Models Reveal Transcriptional Subclusters and MITF-Independent Residual Disease
Year: 2023
Type: supplementary-materials
Abstract: Supplementary File comprising of Supplementary Material and Methods, Supplementary References and Supplementary Figures S1-S7. Figure S1: IHC of melanoma and proliferation markers; Figure S2: Images of fish used for bulk RNA-seq, Figure S3: Heatmaps of most variable genes and MITF target genes; Figure S4: describes transcriptome comparison of the three melanoma models; Figure S5: apoptosis at the site of melanoma regression; Figure S6: fish used for low cell number and single cell RNA-seq; Figure S7: MITF-independent cells present in residual disease and primary tumour.
Authors: Jana Travnickova, Sonia Wojciechowska, Ava Khamseh, Philippe Gautier, Daniel V. Brown, Thomas Lefevre, Alessandro Brombin, Ailith Ewing, Amy Capper, Michaela Spitzer, Ramile Dilshat, Colin A. Semple, Marie E. Mathers, James A. Lister, Eiríkur Steingrimsson, Thierry Voet, Chris P. Ponting, E. Elizabeth Patton
Language: English
Topic: Melanoma and MAPK Pathways
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361898417