Fig. S9 from Metastatic Conditioning of Myeloid Cells at a Subcutaneous Synthetic Niche Reflects Disease Progression and Predicts Therapeutic Outcomes
Year: 2023
Type: other
Abstract: Additional data from post-excision model demonstrating the cohort survival curve and gene expression trajectories. (a) Kaplan-Meier survival analysis comparing TFC and TB mice that received mammary gland excisions. (b-k) Time course analysis for 10 gene panel. Error bars in line plots for gene expression and signature trajectory indicate SEM. The cohort size for each group is decreased by one at Day 21 due recurrence and animal censorship. For longitudinal data, statistics were performed via a linear mixed model. Post hoc simple effects analysis indicates significant differences (p<0.05) between (*) TFC and resistant, (‡) TFC and responsive, (&) resistant and responsive, (#) responsive and responsive Day 0 (pre-excision), and ($) resistant and resistant Day 0 (pre-excision) following significant (p<0.05) or trending (p<0.1) interactions in a two-way ANOVA (see Data File 4 for descriptive statistics, exact F and p values).
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361898741