Fig. S2 from Metastatic Conditioning of Myeloid Cells at a Subcutaneous Synthetic Niche Reflects Disease Progression and Predicts Therapeutic Outcomes
Year: 2023
Type: other
Abstract: Scaffolds from (a) left and (b) right side of a mouse inoculated with parental E0771 which developed a high metastatic burden which metastases present in the (c) brain and (d) lungs. Metastatic lines Br.1 and Lu.1 were derived from the tumor cells from these brain and lung metastases, respectively. Serial inoculation via intracardiac injection and isolation of developed metastases (e) indicated a propensity for the lung derived metastases have an organotropic bias toward lung tissue. (f) Confirmation of fluorescent tumor cells in the scaffolds from a-b was verified by fluorescent microscopy of scaffold tissue sections. (g) In vivo imaging of Br.1 and Lu.1 line 11 days following intracardiac inoculation.
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361898757