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Supplementary Data from Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma

Year: 2023

Type: supplementary-materials

Abstract: Complete and detailed descriptions of materials and methods are in the supplementary information, including animal studies, image registration, hyperpolarized 13C MRI, 18F-FDG PET, EPR imaging, Western blot, Immunohistochemistry, and statistical analysis. A supplementary Figure S contains H&E and CD31 staining of 100 μm thick slices from the center of the xenograft tumors to depict differences in vascularity are not the primer driver for the rim/interior difference in FDG uptake and O2 levels.

DOI: 10.1158/0008-5472.22423344.v1

Authors: Kazutoshi Yamamoto, Jeffrey R. Brender, Tomohiro Seki, Shun Kishimoto, Nobu Oshima, Rajani Choudhuri, Stephen S. Adler, Elaine M. Jagoda, Keita Saito, Nallathamby Devasahayam, Peter L. Choyke, James B. Mitchell, Murali C. Krishna

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361899123

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