Supplementary File from Integrated MicroRNA Network Analyses Identify a Poor-Prognosis Subtype of Gastric Cancer Characterized by the miR-200 Family
Year: 2023
Type: supplementary-materials
Abstract: PDF file 1705K, Supplementary methods, tables, and figures Supplemental Table 1. Characteristics of the 385 GC cases included in the study Supplemental Table 2. Identification of key microRNAs associated with GC survival Supplemental Table 3. Univariate and multivariate Cox proportional hazard model comparing expression of four key microRNAs with survival in GCa Supplemental Table 4. Univariate and multivariate Cox proportional hazard model of the expression of 11 EMT markers and survival in GCa Supplemental Figure 1. Identification of two gastric cancer microRNA subtypes Supplemental Figure 2. Representative qRT-PCR results for miR-200a, miR-200b, and miR-125b Supplemental Figure 3. Validation of the mesenchymal and epithelial subtypes in an independent population from Singapore. Supplemental Figure 4. Validation of the association between key microRNA expression and GC survival Supplemental Figure 5. (A) Forced miR-200b expression decreased ZEB1 expression and markedly decreased the expression of mesenchymal markers vimentin and N-cadherin. (B) N-cadherin/ZEB1 staining of MGC-803 and SGC-7901 cells transfected with miR-200b or miR-Ctrl for 72 hours Cell nuclei were stained with DAPI
Authors: Fengju Song, Da Yang, Ben Liu, Yan Guo, Hong Zheng, Lian Li, Tao Wang, Jinpu Yu, Yanrui Zhao, Ruifang Niu, Han Liang, Hans Winkler, Wei Zhang, Xishan Hao, Kexin Chen
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361906381