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Supplementary Figures 1-7, Table 1 from Differential Protein Stability and ALK Inhibitor Sensitivity of EML4-ALK Fusion Variants

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 151K, Supplementary Figure 1 Different EML4-ALK variants elicit similar proliferation rates Supplementary Figure 2 ALK phosphorylation levels after inhibitor treatment Supplementary Figure 3 Schematic representation of EML4-ALK variants 1, 2, 3a and 3b Supplementary Figure 4 TAE684 induced ALK protein degradation Supplementary Figure 5 Protein stability of EML4-ALK variants Supplementary Figure 6 HSP90 inhibitor sensitivity of EML4-ALK variants 2 and 3a Supplementary Figure 7 Bortezomib sensitivity of EML4-ALK variants

DOI: 10.1158/1078-0432.22451756.v1

Authors: Johannes M. Heuckmann, Hyatt Balke-Want, Florian Malchers, Martin Peifer, Martin L. Sos, Mirjam Koker, Lydia Meder, Christine M. Lovly, Lukas C. Heukamp, William Pao, Ralf Küppers, Roman K. Thomas

Language: English

Topic: Lung Cancer Treatments and Mutations

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361908891

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