Supplementary Figure 1 from Prostate Cancer Progression Correlates with Increased Humoral Immune Response to a Human Endogenous Retrovirus GAG Protein
Year: 2023
Type: supplementary-materials
Abstract: - PDF file 79K, GAG-HERV-K ch22q11.23 features. Endogenous retrovirus K from chromosome 22 is located on the q11.23 region, nearby the BCR, ZDHHC8P, IGLL1 and RGL4 genes. HERV-K ch22q11.23 has GAG-PRO, POL and ENV genes flanked by LTR sequences. The GAG gene has an ORF encoding a 715aa protein that contains P10, P24 and Zinc finger domains. {delta}: deletions; I: early stop codons; --> primer binding regions; ABS: antibody binding site for monoclonal antibody TI-35 (see Supplementary Fig. S3C)
Authors: Bernardo Sgarbi Reis, Achim A. Jungbluth, Denise Frosina, Megan Holz, Erika Ritter, Eiichi Nakayama, Toshiaki Ishida, Yuichi Obata, Brett Carver, Howard Scher, Peter T. Scardino, Susan Slovin, Sumit K. Subudhi, Victor E. Reuter, Caroline Savage, James P. Allison, Jonathan Melamed, Elke Jäger, Gerd Ritter, Lloyd J. Old, Sacha Gnjatic
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361909085