Data Supplement from PI3K/mTOR Inhibition Markedly Potentiates HDAC Inhibitor Activity in NHL Cells through BIM- and MCL-1–Dependent Mechanisms In Vitro and In Vivo
Year: 2023
Type: other
Abstract: Supplementary Fig. 1: Ectopic expression of constitutively active AKT diminished panobinostat toxicity. Supplementary Fig. 2: BEZ235 and panobinostat interact synergistically to kill NHL cell lines. Supplementary Fig. 3: Effects of BEZ235 and panobinostat coadministration on histone acetylation, DNA damage and p21CIP1 expression. Supplementary Fig. 4: Role of Bim in BEZ235/panobinostat toxicity. Supplementary Fig. 5: Effects of BEZ235/panobinostat on Bax, Bak, or Bim binding to Bcl-2, Bcl-xL or Mcl-1 proteins. Supplementary Fig. 6: BEZ235/panobinostat toxicity involves Bax and Bak Supplementary Fig. 7: BEZ235/panobinostat activity in the presence of HS-5-conditioned media. Supplementary Fig. 8: Effect of BEZ235/panobinostat on animal weight
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361909947