Supplementary Methods, Tables 1 - 9 from Concurrent Alterations in TERT, KDM6A, and the BRCA Pathway in Bladder Cancer
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Table S1 presents the clinical characteristics of patients and tumors analyzed in the study. Supplementary Table S2 contains the details about next generation sequencing of the tumor exomes, mapped reads, target depth, and target coverage. Supplementary Table S3 shows the somatic variants that were confirmed by PCR and Sanger sequencing of tumor-normal DNA. Supplementary Table S4 shows the germline variants that were confirmed by PCR and Sanger sequencing of tumor-normal DNA. Supplementary Table S5 includes details about bladder tumor samples with somatic BAP1 mutations. Supplementary Table S6 includes details about the somatic and germline variants that were characterized in the proximal TERT promoter. Supplementary Table S7 examines associations between altered genes to determine if the mutations in different cancer genes were correlated. Supplementary Table S8 shows the genes and biological functions that are associated with interaction networks that include the frequently altered bladder cancer genes. Supplementary Table S9 presents details about the microarray gene expression datasets that were used for the network and gene expression analyses.
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361910102