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Supplementary Figure 1 from Mitochondrial Topoisomerase I (Top1mt) Is a Novel Limiting Factor of Doxorubicin Cardiotoxicity

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 86KB, A, Mitochondrial cross-section area bins after saline or DOX injection (top and bottom panels, respectively). A total of 250 mitochondria from each condition were analyzed from 5 electrons micrographs taken at 3000 X magnifications in 4 to 6 different sections. Two animals were used for each condition. B, Electron microscopy quantification of mitochondria numbers in heart right ventricle after saline or DOX injections. Five electron micrographs taken at 3000 X magnification in 4 to 6 different sections. Two representative animals were used for each condition. Between 1500 to 2700 mitochondria were counted.

DOI: 10.1158/1078-0432.22455446.v1

Authors: Salim Khiati, Ilaria Dalla Rosa, Carole Sourbier, Xuefei Ma, V. Ashutosh Rao, Leonard M. Neckers, Hongliang Zhang, Yves Pommier

Language: English

Topic: Chemotherapy-induced cardiotoxicity and mitigation

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361910363

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