Work

Supplementary Figure 5 from Inhibition of BET Bromodomain Targets Genetically Diverse Glioblastoma

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 1 MB, (A) T4302 CD133+ cells were infected with lentivirus directing expression of non-targeting (NT) shRNA or p53-specific shRNA. Downregulation of p53 was determined by immunoblotting 24 hours after JQ1 treatment. (B) Rb expression was determined by qRT-PCR in T4302 CD133+ cells expressing NT shRNA or Rb-specific shRNA. (C) Immunoblotting of Bcl-xL in T4302 CD133+ cells infected with control lentivirus or virus directing expression of Bcl-xL. (D) Immunoblotting of p21 in T4302 CD133+ cells expressing NT shRNA or p21-specific shRNA.

DOI: 10.1158/1078-0432.22456247.v1

Authors: Zhixiang Cheng, Yuanying Gong, Yufang Ma, Kaihua Lu, Xiang Lu, Larry A. Pierce, Reid C. Thompson, Susanne Muller, Stefan Knapp, Jialiang Wang

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361911931

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