Supplemental Figures 1 - 7 from EGFR Mutations and Resistance to Irreversible Pyrimidine-Based EGFR Inhibitors
Year: 2023
Type: supplementary-materials
Abstract: Supplemental Figures 1 - 7. Figure S1. Sequence tracings from WZ4002 resistant Ba/F3 cells demonstrating EGFR L718Q, C797S and L844V mutations. Figure S2. EGFR Del19 Ba/F3 cells alone or expressing EGFR L718Q were treated with EGF. Figure S3. Structure of TX 2-30. Figure S4. Impact of EGFR L718Q and L844V on sensitivity to WZ4002 and quinazoline based EGFR inhibitors Figure S5. Impact of EGFR Q791R mutation. Figure S6. EGFR L718Q and L844V cause resistance in trans in EGFR mutant NSCLC cell lines. Figure S7. Evaluation of cetuximab on EGFR dimerization and growth in EGFR C797S expressing cells.
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361912343