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Supplementary Table 2 and 3 from Focal Adhesion Kinase Regulates the DNA Damage Response and Its Inhibition Radiosensitizes Mutant KRAS Lung Cancer

Year: 2023

Type: supplementary-materials

Abstract: Supplementary Table 2. The table shows the IC50 for FAKi PF-562, 271 for the indicated cell lines. Supplementary Table 3. The table shows the Dq, Do and Dose enhancement ratios of NSCLC cells treated as indicated. Dose enhancement ratios at LD50 and LD20 levels were calculated by direct examination of survival curves. Survival parameters (i.e., Dq and Do) were also derived from survival curves shown in Fig. 4 using the relationship, loge n = Dq/Do.

DOI: 10.1158/1078-0432.22458446.v1

Authors: Ke-Jing Tang, Jerfiz D. Constanzo, Niranjan Venkateswaran, Margherita Melegari, Mariya Ilcheva, Julio C. Morales, Ferdinandos Skoulidis, John V. Heymach, David A. Boothman, Pier Paolo Scaglioni

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361917756

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