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Supplementary Figures S1 - S2 from Tumor-Targeted Synergistic Blockade of MAPK and PI3K from a Layer-by-Layer Nanoparticle

Year: 2023

Type: supplementary-materials

Abstract: Fig. S1. Drug-interaction matrix plotting cell killing observed in excess of the additive Bliss expectation between MEK and PI3K inhibition in Pt-resistant epithelial ovarian carcinoma (OVCAR3; 0.20-100 microM, 48 h).ϑ Fig. S2. Changes in serum cytokine levels following a single i.v. bolus of LbL nanoparticles in immuno-competent BALC/c mice at t=0 h. Error represents SD of 4 technical replicates from n=3 mice.

DOI: 10.1158/1078-0432.22458524.v1

Authors: Erik C. Dreaden, Yi Wen Kong, Stephen W. Morton, Santiago Correa, Ki Young Choi, Kevin E. Shopsowitz, Kasper Renggli, Ronny Drapkin, Michael B. Yaffe, Paula T. Hammond

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361918044

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