Supplementary Figure 1 from Topical Application of a Mucoadhesive Freeze-Dried Black Raspberry Gel Induces Clinical and Histologic Regression and Reduces Loss of Heterozygosity Events in Premalignant Oral Intraepithelial Lesions: Results from a Multicentered, Placebo-Controlled Clinical Trial
Year: 2023
Type: supplementary-materials
Abstract: PDF file - 1911KB, Immunoblot analyses of proteins associated with either keratinocyte differentiation (TGase 1, Involucrin, Loricrin, Cytokeratin 10/13) or local enteric recycling (UDP-Glc DH, UGT1A) in biopsy tissues of clinical trial participants. As not all OIN lesions had sufficient size to obtain tissue for Western analyses, only samples from the larger OIN lesions are represented. We have previously confirmed that these enzymes of interest reside almost exclusively in the epithelia. Pan cytokeratin was therefore used as the protein loading control.
Authors: Susan R. Mallery, Meng Tong, Brian S. Shumway, Alice E. Curran, Peter E. Larsen, Gregory M. Ness, Kelly S. Kennedy, George H. Blakey, George M. Kushner, Aaron M. Vickers, Brian Han, Ping Pei, Gary D. Stoner
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361919000