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Supplementary Figures from Wide Variability in the Time Required for Immunotoxins to Kill B Lineage Acute Lymphoblastic Leukemia Cells: Implications for Trial Design

Year: 2023

Type: supplementary-materials

Abstract: Figure S1. KOPN-8 from murine BM has similar levels of CD22 and RIT sensitivity as in cell culture Figure S2. LMB-11-Alexa 647 in KOPN-8 from murine BM reaches maximal signal intensity after only 1 h circulation time Figure S3. Compared to the most active rIT HA22, introduction of every new variable in LMB-11 reduced activity and increased exposure time against KOPN-8.

DOI: 10.1158/1078-0432.22460082.v1

Authors: Fabian Müller, Tyler Cunningham, Xiu Fen Liu, Alan S. Wayne, Ira Pastan

Institutions: National Institutes of Health, National Cancer Institute, Center for Cancer Research, University of Southern California, Children's Hospital Los Angeles

Language: English

Topic: Toxin Mechanisms and Immunotoxins

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361919024

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