Work

Supplemental Figure S4 from Targeting Acidity in Pancreatic Adenocarcinoma: Multispectral Optoacoustic Tomography Detects pH-Low Insertion Peptide Probes In Vivo

Year: 2023

Type: supplementary-materials

Abstract: Supplemental Figure S4: (A) S2013 mouse demonstrate localization of V7-750 probe, but not K7-750 to the region of the tumor bed, signal intensity in the pancreas tumor of S2013 mice with injection of V7-750 is 578.3 MSOT a.u., compared to 5.1 for K7-750 with p=0.0005. K7-750 signal was largely localized in the kidney.(B) Orthogonal views of the pancreatic tumor bed at 4 hours demonstrate distribution of V7-750 probe signal throughout the tumor bed at 4 hours, while minimal accumulation is observed with K7-750.

DOI: 10.1158/1078-0432.22460570.v1

Authors: Charles W. Kimbrough, Anil Khanal, Matthew Zeiderman, Bigya R. Khanal, Neal C. Burton, Kelly M. McMasters, Selwyn M. Vickers, William E. Grizzle, Lacey R. McNally

Language: English

Topic: Photoacoustic and Ultrasonic Imaging

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361919636

Cites:

Cited by:

Related to: 10