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Supplemental Figure 1 from Toxicity Attribution in Phase I Trials: Evaluating the Effect of Dose on the Frequency of Related and Unrelated Toxicities

Year: 2023

Type: supplementary-materials

Abstract: Dose-toxicity curves by agent class (cytotoxic or molecular) and attribution (2-tier system). Black points represent the proportion of patients in a dose group experiencing grade {greater than or equal to}1 toxicity with the specified category and attribution. Red points represent the proportion of patients experiencing grade {greater than or equal to}3 toxicity within the specified category and attribution. Lines represent a fitted logistic regression curve with % of maximum administered dose (MAD) as a continuous covariate and p-values are from the same model.

DOI: 10.1158/1078-0432.22461651.v1

Authors: Anne Eaton, Alexia Iasonos, Mrinal M. Gounder, Erika G. Pamer, Alexander Drilon, Diana Vulih, Gary L. Smith, S. Percy Ivy, David R. Spriggs, David M. Hyman

Language: English

Topic: Statistical Methods in Clinical Trials

Subfield: Statistics and Probability

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361920143

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