Work

Supplemental Figures from Fibroblast Subtypes Regulate Responsiveness of Luminal Breast Cancer to Estrogen

Year: 2023

Type: supplementary-materials

Abstract: SFig. 1: Cellular morphology defines tumor cell from stroma.; SFig. 2: Primary derived stroma from cancer-associated and normal breast tissue is highly enriched for fibroblasts.; SFig 3: Immortalized primary derived fibroblasts express high levels of vimentin and FSP1.; SFig. 4: Primary derived cancer fibroblasts are highly similar to normal bone marrow-derived fibroblasts.; SFig. 5: Influence from CD146neg fibroblasts on ER+ breast cancer cells reduces ER expression and estrogen dependency.; SFig 6. Influence from CD146neg fibroblasts on ER+ breast cancer is predictive of decreased recurrence-free survival.

DOI: 10.1158/1078-0432.22462613.v1

Authors: Heather M. Brechbuhl, Jessica Finlay-Schultz, Tomomi M. Yamamoto, Austin E. Gillen, Diana M. Cittelly, Aik-Choon Tan, Sharon B. Sams, Manoj M. Pillai, Anthony D. Elias, William A. Robinson, Carol A. Sartorius, Peter Kabos

Language: English

Topic: Estrogen and related hormone effects

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361920789

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