Multiplex genome editing to generate universal CAR T cells resistant to PD1 inhibition sup from Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition
Year: 2023
Type: other
Abstract: Treating cancers using allogeneic universal CAR T cells resistant to PD1 inhibition generated by multiplex genome editing via CRISPR/Cas9 Supplementary Figure 1. Strategy of introducing CRISPR/Cas9 into T cells. Supplementary Figure 2. Multiple deliveries of gRNAs disrupts genes in human primary T cells with high efficiency without impairing effector function. Supplementary Figure 3. Proliferation test of CD3neg T cells. Supplementary Figure 4. Reduced alloreactivity of TCR and B2M double-disrupted T cells. Supplementary Figure 5. GVHD effect of gene-modified CAR T cells Supplementary Figure 5. Generation of universal CART cells deficient of PD1. Supplementary table 1
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361924288