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Supplementary methods and references, Supplementary Figures 1-9 from T Cells Expressing Checkpoint Receptor TIGIT Are Enriched in Follicular Lymphoma Tumors and Characterized by Reversible Suppression of T-cell Receptor Signaling

Year: 2023
Type: supplementary-materials
Abstract: Supplementary Figure 1. IL-21 produc􀆟on is reduced in CD4 FL T cells; Supplementary Figure 2. TCR-induced signaling effectors have different kine􀆟c; Supplementary Figure 3. Iden􀆟fica􀆟on of T-cell subsets; Supplementary Figure 4. Distribu􀆟on of T-cell subsets in FL LN; Supplementary Figure 5. Expression pa􀆩erns of co-inhibitory receptors in CD8 and CD4 T-cell subsets; Supplementary Figure 6. Contribu􀆟on of Tregs among CD4+TIGIT+ T cells; Supplementary Figure 7. TIGIT is a highly expressed co-inhibitory receptor in FL; Supplementary Figure 8. TIGIT expression is stable over 􀆟me; Supplementary Figure 9. Recovery of TCR-induced signaling in TIGIT+ CD8+ FL T cells is robust.
DOI: 10.1158/1078-0432.22465035.v1
Authors: Sarah E. Josefsson, Kanutte Huse, Arne Kolstad, Klaus Beiske, Daniela Pende, Chloé B. Steen, Else Marit Inderberg, Ole Christian Lingjærde, Bjørn Østenstad, Erlend B. Smeland, Ronald Levy, Jonathan M. Irish, June H. Myklebust
Language: English
Subfield: Immunology
Open Access status: gold
OpenAlex ID: W4361925900
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