Work

Figure S1-S6 from Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer

Year: 2023

Type: other

Abstract: Supplementary Figure S1. Hypoxia increases stem gene expression and stabilizes HIF proteins. Supplementary Figure S2. Chemotherapy enriches for colorectal C-IC markers and increases expression of Wnt and HIF targets. Supplementary Figure S3. Growth of colorectal cancer PDXs shown in Figure 4. Supplementary Figure S4. Hypoxic fraction in a panel of colorectal cancer PDX models. Supplementary Figure S5. Growth of colorectal cancer PDXs shown in Figure 5. Supplementary Figure S6. Hypoxia gene sets are prognostic for clinical outcome of colon cancer patients.

DOI: 10.1158/1078-0432.22465230.v1

Authors: Jennifer Haynes, Trevor D. McKee, Andrew Haller, Yadong Wang, Cherry Leung, Deena M.A. Gendoo, Evelyne Lima-Fernandes, Antonija Kreso, Robin Wolman, Eva Szentgyorgyi, Douglass C. Vines, Benjamin Haibe-Kains, Bradly G. Wouters, Ur Metser, David A. Jaffray, Myles Smith, Catherine A. O'Brien

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361926295

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