Work

Supplementary Figure S3 from PTEN Loss Promotes Intratumoral Androgen Synthesis and Tumor Microenvironment Remodeling via Aberrant Activation of RUNX2 in Castration-Resistant Prostate Cancer

Year: 2023

Type: supplementary-materials

Abstract: Panel A and B show that treatment of PC-3 PCa cells with the PI3K inhibitor NVP-BEZ235 or the AKT inhibitor MK2206 downregulated expression of CYP11A1 and CYP17A1 mRNA. Panel C-G show the effect of RUNX2 knockdown, overexpression of constitutively active FOXO1 (FOXO1-A3), OCN knockdown, GPRC6A knockdown and ectopic expression of CREB on expression of CYP11A1 and CYP17A1 mRNA in PC-3 cells.

DOI: 10.1158/1078-0432.22465442.v1

Authors: Yinhui Yang, Yang Bai, Yundong He, Yu Zhao, Jiaxiang Chen, Linlin Ma, Yunqian Pan, Michael Hinten, Jun Zhang, R. Jeffrey Karnes, Manish Kohli, Jennifer J. Westendorf, Benyi Li, Runzhi Zhu, Haojie Huang, Wanhai Xu

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361927259

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