Figure S5 from Single-Cell Analyses of Prostate Cancer Liquid Biopsies Acquired by Apheresis
Year: 2023
Type: other
Abstract: Organoid cultures of CTCs acquired by apheresis from patient P05: a) Dendrogram and heat map of hierarchical clustering, based on Euclidean distance, for patient P05 evaluating CTC (green bars) and organoid CNAs (red). b) Micrographs of two organoids from P05 with scale bar in bottom left (100µm). c) Phylogenetic tree showing the cultured organoids have CNA that cluster with CTCs. d) Two organoids and 3 CTCs with truncal CNA including shared BRCA2 loss and AR amplification but sub-clonal chromosome 1 aberrations.
Authors: Maryou B. Lambros, George Seed, Semini Sumanasuriya, Veronica Gil, Mateus Crespo, Mariane Fontes, Rob Chandler, Niven Mehra, Gemma Fowler, Berni Ebbs, Penny Flohr, Susana Miranda, Wei Yuan, Alan Mackay, Ana Ferreira, Rita Pereira, Claudia Bertan, Ines Figueiredo, Ruth Riisnaes, Daniel Nava Rodrigues, Adam Sharp, Jane Goodall, Gunther Boysen, Suzanne Carreira, Diletta Bianchini, Pasquale Rescigno, Zafeiris Zafeiriou, Joanne Hunt, Deirdre Moloney, Lucy Hamilton, Rui P. Neves, Joost Swennenhuis, Kiki Andree, Nikolas H. Stoecklein, Leon W.M.M. Terstappen, Johann S. de Bono
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361932630