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Figure S2 from PDK1 Mediates NOTCH1-Mutated Head and Neck Squamous Carcinoma Vulnerability to Therapeutic PI3K/mTOR Inhibition

Year: 2023
Type: other
Abstract: Figure S2. Relationship of NOTCH1 protein expression, activation, and mutation in head and neck squamous cell carcinoma (HNSCC) tumors and cell lines. A. The basal protein expression levels of NOTCH1 were compared between NOTCH1WT (n=170) and NOTCH1MUT (n=38) tumors available in The Cancer Genome Atlas (TCGA) using a two-sample t-test. B-E. Basal NOTCH1 (B and E) and NOTCH intracellular domain (NICD) (C and D) protein expression was compared with drug sensitivity as measured by area under curve (AUC) for all 59 HNSCC cell lines (B and C), NOTCH1WT cells only (n=45) (D), and with NOTCH1MUT cells only (n=14) (E). P values were calculated with Spearman rho correlation analysis. The dashed blue lines indicate trend line and the shaded area represent 95% confidence interval.
DOI: 10.1158/1078-0432.22469312.v1
Authors: Vaishnavi Sambandam, Mitchell J. Frederick, Li Shen, Pan Tong, Xiayu Rao, Shaohua Peng, Ratnakar Singh, Tuhina Mazumdar, Chenfei Huang, Qiuli Li, Curtis R. Pickering, Jeffery N. Myers, Jing Wang, Faye M. Johnson
Language: English
Open Access status: gold
OpenAlex ID: W4361932685
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