Supplementary figures 1-8 from Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Figure S1. Additional analysis of siRNA effects on ciliation and target depleton. Supplementary Figure S2. Sorafenib is similar to sunitinib in inducing ciliary resorption. Supplementary Figure S3. Effect of compounds on AURKA catalytic activity. Supplementary Figure S4. Representative images demonstrating the effect of sunitinib (A) and ganetespib (B) on cilia resorption in hTERT-RPE1-Arl13b-GFP cells. Supplementary Figure S5. Cilia length upon treatment with indicated cilia-stabilizing compounds in hTERT-RPE1 (A) and NIH3T3 (B) cell lines. Supplementary Figure S6. Drug effects on ciliation correspond to changes in cell cycle over time. Supplementary Figure S7. Erlotinib increases ciliation in CFPAC-1 but not in PNX0010 cell line. Supplementary Figure S8. Representative Western blot images and quantitation of PDGF-AA-induced activation of PDGFR and MEK1/2 in NIH3T3 cells, related to Figures 3F, G.
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361935477