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Supplementary Data from 64Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer

Year: 2023
Type: supplementary-materials
Abstract: Fig. S1. MM-302 tumor deposition in preclinical xenografts as a function of HER2 expression. Fig. S2. Preclinical assessment of minimum 64Cu-MM-302 tumor delivery for anti-tumor activity. Fig. S3. Maximum intensity projection images of selected patients with average and rapid clearance of 64Cu-MM-302. Fig. S4. Stability of 64Cu-MM-302 in patients. Fig. S5. Hepatic tumor lesion with similar uptake as normal liver tissue. Fig. S6. Estimated parameter values (k1, k-1, VVF) for lesions from 3 patients who underwent 3 scans. Table S1. Model parameters for tracer kinetic modeling of 64Cu-MM-302 liposome transport into and out of tumors. Table S2. Patient Demographic (n=19). Table S3. Radiation Dosimetry of 64Cu-MM-302 (n=11).
DOI: 10.1158/1078-0432.22469117.v1
Authors: Helen Lee, Anthony F. Shields, Barry A. Siegel, Kathy D. Miller, Ian Krop, Cynthia X. Ma, Patricia M. LoRusso, Pamela N. Munster, Karen Campbell, Daniel F. Gaddy, Shannon C. Leonard, Elena Geretti, Stephanie J. Blocker, Dmitri B. Kirpotin, Victor Moyo, Thomas J. Wickham, Bart S. Hendriks
Language: English
Field: Medicine
Open Access status: gold
OpenAlex ID: W4361935504
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