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Supplementary Figure 7A, B from Somatic Epigenetic Silencing of RIPK3 Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma

Year: 2023
Type: supplementary-materials
Abstract: Re-expression of RIPK3 expression triggers necroptosis in RIPK3-negative MM cell lines, and RIPK3 inhibition rescues the cell death caused by necroptosis. A, RIPK3-negative MM cell lines M12 and M22 were transduced with WPI lentivirus expressing RIPK3 WT or empty vector and treated with the apoptosis inhibitor zVAD and/or the RIPK3 inhibitor GSK'872 for 1-4 d. Results of immunoblot analysis (24 h) and clonogenic assay (4 d) are shown. B, Cell viability determined with hemocytometer and trypan blue dye exclusion test.
DOI: 10.1158/1078-0432.22473987.v1
Authors: Yinfei Tan, Eleonora Sementino, Mitchell Cheung, Suraj Peri, Craig W. Menges, Anna-Mariya Kukuyan, Ting Zhang, Vladimir Khazak, Lauren A. Fox, Eric A. Ross, Suresh Ramanathan, Suresh C. Jhanwar, Raja M. Flores, Siddharth Balachandran, Joseph R. Testa
Language: English
Open Access status: gold
OpenAlex ID: W4361936182
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