Supplementary Figure S1 from Phase I Study of Lysine-Specific Demethylase 1 Inhibitor, CC-90011, in Patients with Advanced Solid Tumors and Relapsed/Refractory Non-Hodgkin Lymphoma
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Figure S1. Antitumor Activity of CC-90011 in SCLC Patient-Derived Xenografts (PDXs). The effects of CC-90011 on a human SCLC PDX (LXFS 1129) model implanted subcutaneously in female athymic nude mice (NMRI-Foxn1nu). Female mice (n = 8) bearing the SCLC tumors were dosed orally with either 1.5 or 5 mg/kg/day of CC-90011 for 60 consecutive days or 10 mL/kg 0.5% methyl cellulose vehicle as a control. SCLC, small cell lung cancer. Data cutoff: 28 January 2019.
Authors: Antoine Hollebecque, Stefania Salvagni, Ruth Plummer, Nicolas Isambert, Patricia Niccoli, Jaume Capdevila, Giuseppe Curigliano, Victor Moreno, Patricia Martin-Romano, Eric Baudin, Marina Arias, Sheila Mora, Juan de Alvaro, Jorge Di Martino, Josep L. Parra-Palau, Tania Sánchez-Pérez, Ida Aronchik, Ellen H. Filvaroff, Manisha Lamba, Zariana Nikolova, Johann S. de Bono
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361938344