Figure S5 from LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors
Year: 2023
Type: other
Abstract: Supplementary Figure 5. Model for LXH254 interactions with RAF monomers and dimers (A). (B) Upper panel, simulated structure of ARAF (green) overlaid on the structure of BRAF (blue). LXH254 interacting with ARAF is shown in yellow and with BRAF in purple. (B) Lower panel, enhanced view of hydrogen bond interactions between LXH254 (purple) and the backbone carbonyl of F595 of BRAF (Blue) and LXH254 (yellow) and backbone carbonyl of ARAF (green).
Authors: Kelli-Ann Monaco, Scott Delach, Jing Yuan, Yuji Mishina, Paul Fordjour, Emma Labrot, Daniel McKay, Ribo Guo, Stacy Higgins, Hui Qin Wang, Jinsheng Liang, Karen Bui, John Green, Peter Aspesi, Jessi Ambrose, Felipa Mapa, Lesley Griner, Mariela Jaskelioff, John Fuller, Kenneth Crawford, Gwynn Pardee, Stephania Widger, Peter S. Hammerman, Jeffrey A. Engelman, Darrin D. Stuart, Vesselina G. Cooke, Giordano Caponigro
Language: English
Topic: Melanoma and MAPK Pathways
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361939264