Work

Figure S4 from Regulation of OATP1B1 Function by Tyrosine Kinase–mediated Phosphorylation

Year: 2023

Type: other

Abstract: Assessment of LYN kinase expression, and function in the presence of various TKIs. (A) Detection of LYN protein expression in human hepatocyte and spleen lysates as determined by Western blot analysis. Prior to analysis, spleen (1:10) and liver (1:1) lysates were diluted. Protein expression of GAPDH was measured as a loading control. The image is a representative of 3 independent experiments. (B) LYN activity in the presence of various TKI concentrations (10-doses) was determined using a kinase assay. (C) Regression of LYN IC50 values of several TKIs and percent of LYN inhibition.

DOI: 10.1158/1078-0432.22481136.v1

Authors: Elizabeth R. Hayden, Mingqing Chen, Kyle Z. Pasquariello, Alice A. Gibson, James J. Petti, Shichen Shen, Jun Qu, Su Sien Ong, Taosheng Chen, Yan Jin, Muhammad Erfan Uddin, Kevin M. Huang, Aviv Paz, Alex Sparreboom, Shuiying Hu, Jason A. Sprowl

Language: English

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361939657

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