Work

Figure S5 from Regulation of OATP1B1 Function by Tyrosine Kinase–mediated Phosphorylation

Year: 2023

Type: other

Abstract: Assessment of lapatinib or trametinib as OATP1B1 substrates. (A) Percent uptake of 3H-lapatinib (1 µM) in OATP1B1 overexpressing HEK293 cells relative to uptake in HEK293 cells transfected with a vector control (VC) (n=3, from a single experiment). (B) Lineweaver-Burke plot for OATP1B1-dependent uptake in HEK293-OATP1B1 cells treated with various concentrations of trametinib (0 - 5 µM) and 8FcA (0 - 40 µM) (n=9, and a combination of 3 independent experiments) . * denotes P < 0.001 vs VC. All values represent mean {plus minus} SEM.

DOI: 10.1158/1078-0432.22481133

Authors: Elizabeth R. Hayden, Mingqing Chen, Kyle Z. Pasquariello, Alice A. Gibson, James J. Petti, Shichen Shen, Jun Qu, Su Sien Ong, Taosheng Chen, Yan Jin, Muhammad Erfan Uddin, Kevin M. Huang, Aviv Paz, Alex Sparreboom, Shuiying Hu, Jason A. Sprowl

Language: English

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361890308

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