Work

Data from Wnt/β-Catenin Signaling in T-Cell Immunity and Cancer Immunotherapy

Year: 2023

Type: other

Abstract: Wnt ligands are lipid-modified secreted glycoproteins that regulate embryonic development, cell fate specification, and the homeostasis of self-renewing adult tissues. In addition to its well-established role in thymocyte development, recent studies have indicated that Wnt/β-catenin signaling is critical for the differentiation, polarization, and survival of mature T lymphocytes. Here, we describe our current understanding of Wnt signaling in the biology of post-thymic T cells, and discuss how harnessing the Wnt/β-catenin pathway might improve the efficacy of vaccines, T-cell–based therapies, and allogeneic stem cell transplantation for the treatment of patients with cancer. Clin Cancer Res; 16(19); 4695–701. ©2010 AACR.

DOI: 10.1158/1078-0432.c.6519596.v1

Authors: Luca Gattinoni, Yun Ji, Nicholas P. Restifo

Institutions: National Institutes of Health, National Cancer Institute, Center for Cancer Research

Language: English

Topic: Wnt/β-catenin signaling in development and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Funders: National Institutes of Health, National Cancer Institute

OpenAlex ID: W4361949688

Cites: 42

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Related to: 10