Supplementary Data TS1 from Tumor Dynamic Model-Based Decision Support for Phase Ib/II Combination Studies: A Retrospective Assessment Based on Resampling of the Phase III Study IMpower150
Year: 2023
Type: supplementary-materials
Abstract: Supplementary Table 1: Parameter estimates of the TGI-OS model after removing study IMpower150 from the integrated NSCLC model in reference 15 Parameter Estimate SE z p (Intercept) 3.41 0.201 17 6.44E-65 logKG -0.621 0.0256 -24.3 4.46E-130 C-reactive protein (mg/L) -0.00374 0.000403 -9.29 1.60E-20 ECOG (1 vs. 0) -0.179 0.0348 -5.14 2.74E-07 Number of metastatic sites -0.0723 0.0153 -4.73 2.21E-06 Race (Asian vs. non-Asian) 0.194 0.0508 3.82 0.000135 Albumin (g/L) 0.0135 0.0036 3.74 0.000184 IC or TC > 0 vs. IC and TC = 0 0.131 0.0331 3.96 7.64E-05 Lactate dehydrogenase (U/L) -0.00012 4.17E-05 -2.8 0.00515 Neutrophil-to-lymphocyte ratio -0.0165 0.00379 -4.36 1.27E-05 Lines of therapy (2+ vs. 1) -0.103 0.0357 -2.88 0.00403 Liver metastasis (yes vs. no) -0.121 0.0452 -2.68 0.00734 Log(scale) -0.276 0.0185 -14.9 2.82E-50 Note: Out of 500 bootstrap replicates, 20 (4.0%) had estimation step minimization terminated and 53 (10.6%) did not achieve covariance step.
Language: English
Subfield: Statistics and Probability
Field: Mathematics
Domain: Physical Sciences
Open Access status: gold
OpenAlex ID: W4361955146