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Supplementary Methods, Figure Legends, Tables 1 - 9 from Systems Analysis of BCL2 Protein Family Interactions Establishes a Model to Predict Responses to Chemotherapy

Year: 2023
Type: supplementary-materials
Abstract: PDF file - 237K, Supplementary Table 1: Translation of protein interactions into Ordinary Differential Equations. Supplementary Table 2: Pseudo-reactions for degradation and degradation rates as used in the model. Supplementary Table 3: Pseudo-reactions and kinetics for inhibition of BH3 only proteins and effectors BAK and BAX by anti-apoptotic proteins. Supplementary Table 4: BAK and BAX activation and BAK inhibition by VDAC2. Supplementary Table 5: Effector homo-oligomerization. Supplementary Table 6: Modeling apoptosis sensitizers ABT-737 and ApoG2. Supplementary Table 7 Two tBID chimeras were modeled to reproduce the findings of Llambi et al. Supplementary Table 8: BCL2 protein quantification of CRC cell lines. Supplementary Table 9: BCL2 protein quantification of CRC patient samples.
DOI: 10.1158/0008-5472.22399170.v1
Authors: Andreas U. Lindner, Caoimhín G. Concannon, Gerhardt J. Boukes, Mary D. Cannon, Fabien Llambi, Deborah Ryan, Karen Boland, Joan Kehoe, Deborah A. McNamara, Frank Murray, Elaine W. Kay, Suzanne Hector, Douglas R. Green, Heinrich J. Huber, Jochen H.M. Prehn
Language: English
Open Access status: gold
OpenAlex ID: W4361955329
Cites: 33
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Related to: 10