Work

Data from NF1 Inactivation Revs Up Ras in Adult Acute Myelogenous Leukemia

Year: 2023

Type: other

Abstract: Mutations in the Ras pathway are common in myeloid malignancies. NF1, a tumor suppressor and negative regulator of Ras, is inactivated in a subset of adult acute myelogenous leukemia (AML) cases. Loss of NF1 function sensitizes cells to inhibition of mammalian target of rapamycin (mTOR), a downstream effector of Ras activation, highlighting a potential therapeutic opportunity for some AML patients. Clin Cancer Res; 16(16); 4074–6. ©2010 AACR.

DOI: 10.1158/1078-0432.c.6519389

Authors: Ann Mullally, Benjamin L. Ebert

Institutions: Brigham and Women's Hospital, Harvard University

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361961147

Cites: 9

Cited by:

Related to: 10