Supplementary Figures from IL-21 Enhances Natural Killer Cell Response to Cetuximab-Coated Pancreatic Tumor Cells
Year: 2023
Type: supplementary-materials
Abstract: Figure S1. IL-21 enhances antibody-dependent cellular cytotoxicity of NK cells against colon cancer cell lines that over-express EGFR. Figure S2. Human NK cell IFN-γ production increases over time. Figure S3. Human NK cells secrete high levels of pro-inflammatory cyotkines/chemokines in the presence of IL-21 and cetuximab-coated AsPc1 pancreatic cancer cells. Figure S4. NK cell signal transduction is enhanced by IL-21 receptor and Fc receptor engagement by cetuximab-coated wild-type KRAS BxPc3 tumor cells. Figure S5. Transfection of human EGFR into the Panc02 cell line does not significantly affect tumor growth. Figure S6. Expression of EGFR is necessary for the efficacy of IL-21 and cetuximab. Figure S7. Depletion of monocytes does not affect the efficacy of IL-21 and cetuximab combination therapy.
Authors: Elizabeth L. McMichael, Alena Cristina Jaime-Ramirez, Kristan D. Guenterberg, Eric Luedke, Lakhvir S. Atwal, Amanda R. Campbell, Zhiwei Hu, Armika S. Tatum, Sri Vidya Kondadasula, Xiaokui Mo, Susheela Tridandapani, Mark Bloomston, E. Christopher Ellison, Terence M. Williams, Tanios Bekaii-Saab, William E. Carson
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361967709