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Figure S1 from PDK1 Mediates NOTCH1-Mutated Head and Neck Squamous Carcinoma Vulnerability to Therapeutic PI3K/mTOR Inhibition

Year: 2023
Type: other
Abstract: Figure S1:Landscape of sensitivity to PI3K/mTOR pathway inhibitors in head and neck squamous cell carcinoma (HNSCC) cell lines. A. HNSCC cell lines (n=59) were incubated with seven PI3K/mTOR pathway inhibitors. B. The 70% inhibitory concentration (IC70) values for each drug were plotted. Each data point represents one cell line. C. Spearman correlation analysis was used to assess the association of each drug's IC70 value with those of the other drugs. The drugs included seven PI3K/mTOR pathway inhibitors (red text) and three cell cycle kinase inhibitors (blue text). The heat map shows the Spearman correlation values for each drug combination; unsupervised clustering showed that all PI3K/mTOR pathway inhibitors exhibited similar sensitivity patterns.
DOI: 10.1158/1078-0432.22469315.v1
Authors: Vaishnavi Sambandam, Mitchell J. Frederick, Li Shen, Pan Tong, Xiayu Rao, Shaohua Peng, Ratnakar Singh, Tuhina Mazumdar, Chenfei Huang, Qiuli Li, Curtis R. Pickering, Jeffery N. Myers, Jing Wang, Faye M. Johnson
Language: English
Open Access status: gold
OpenAlex ID: W4361967755
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