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Supplementary Tables 1 - 4 from Translating the Therapeutic Potential of AZD4547 in FGFR1-Amplified Non–Small Cell Lung Cancer through the Use of Patient-Derived Tumor Xenograft Models

Year: 2023

Type: supplementary-materials

Abstract: PDF file - 94K, Supplementary Table 1. AZD4547 GI50 comparisons between FGFR1-amplified DMS114 and EGFR-mutant NCI-H1975 cell lines. Supplementary Table 2. Dynamic modulation of pERK, pS6, Ki67 and CC3 markers in model L121 tumor sections treated with a single dose of 12.5mg/kg AZD4547. Supplementary Table 3. Statistical association analysis of tumor histology and patient smoking status. Supplementary Table 4. FGFR1 amplification shows high mutual exclusivity with EGFR, Kras and EML4-ALK status in Chinese NSCLC.

DOI: 10.1158/1078-0432.22452458.v1

Authors: Jingchuan Zhang, Lin Zhang, Xinying Su, Ming Li, Liang Xie, Florian Malchers, ShuQiong Fan, XiaoLu Yin, YanPing Xu, Kunji Liu, Zhengwei Dong, Guanshan Zhu, Ziliang Qian, Lili Tang, Ping Zhan, Qunsheng Ji, Elaine Kilgour, Paul D. Smith, A. Nigel Brooks, Roman K. Thomas, Paul R. Gavine

Language: English

Topic: Lung Cancer Treatments and Mutations

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361968356

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