Work

Supplementary Movie S3 from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G2/M Phases

Year: 2023

Type: supplementary-materials

Abstract: Supplementary Movie S3 - MOV file 6227K, Time-lapse imaging of treatment dynamics of FUCCI-expressing dormant tumor spheres treated with OBP-301 or conventional therapy in three-dimensional culture. Tumor spheres were treated with mock (upper left), OBP-301 (upper right), cisplatin (lower left) or radiation (lower right). Images were acquired every 20 min. The playback speed is 30,240 x real time. Total imaging time = 7days. The cells in G0/ G1, S, or G2/M phases appear red, yellow, or green, respectively

DOI: 10.1158/1078-0432.22449762

Authors: Shuya Yano, Hiroshi Tazawa, Yuuri Hashimoto, Yasuhiro Shirakawa, Shinji Kuroda, Masahiko Nishizaki, Hiroyuki Kishimoto, Futoshi Uno, Takeshi Nagasaka, Yasuo Urata, Shunsuke Kagawa, Robert M. Hoffman, Toshiyoshi Fujiwara

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361968767

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