Supplementary Figures from PIK3CA and AKT1 Mutations Have Distinct Effects on Sensitivity to Targeted Pathway Inhibitors in an Isogenic Luminal Breast Cancer Model System
Year: 2023
Type: supplementary-materials
Abstract: PDF file, 526K, Supplementary Figure 1. Genomic DNA and cDNA sequencing verification of additional gene-targeted MCF-7 derivatives. Supplementary Figure 2. PI3K pathway signaling in low serum conditions. Supplementary Figure 3. Estrogenic stimulation of growth. Supplementary Figure 4. GDC-0941 and MK-2206 treatment of MCF-7 cells and three gene-targeted derivatives with a single mutant copy of PIK3CA (Het 1-3). Supplementary Figure 5. MK-2206 treatment of isogenic MCF-10A cells. Supplementary Figure 6. Perifosine treatment of MCF-7 and cells with wild type PIK3CA and AKT1, mutant PIK3CA, or mutant AKT1 genes.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361882065