Supplementary Data from A Novel Locus Predicts Spermatogenic Recovery among Childhood Cancer Survivors Exposed to Alkylating Agents
Year: 2023
Type: supplementary-materials
Abstract: Sup Table 1: Age-adjusted testosterone, FSH and LH levels in community controls. Sup Table 2: Non-genetic model for sperm concentration (millions/mL) among 201 unirradiated male survivors who were exposed to CED. Sup Table 3: Sperm characteristics in oligospermic and normospermic semen analysis participants in the discovery sample. Sup Table 4: Rare variant associations for sperm concentration (millions/mL) showing statistical significance in standard burden and SKAT tests and their results based on permutation-based analyses. Sup Table 5: Meta-analysis of discovery and replications results for the chromosome 7q21.3 locus associated with sperm concentration. Sup Table 6: The association of rs7784118 with sperm concentration in the discovery sample, stratified by endocrine parameters. Sup Table 7: Consistency of two different semen analyses for the 16 male survivors in the discovery sample. Sup Figure 1: Principal component analysis (PCA) of survivors in the SJLIFE WGS dataset. Sup Figure 2: Quantile-quantile plot for the common variant analysis of sperm concentration in the discovery sample. Sup Figure 3: Distribution of sperm concentration (millions/mL) with respect to genotypes of rs7784118 in the discovery cohort.
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361969023