Figures S1-11 from Proteomic Analysis of CSF from Patients with Leptomeningeal Melanoma Metastases Identifies Signatures Associated with Disease Progression and Therapeutic Resistance
Year: 2023
Type: other
Abstract: Supplementary Figures 1-11. 1. CSF cytology of leptomeningeal patient cohort. 2. Additional clinical timelines of leptomeningeal patient cohort 3. Patient MRIs 4. RNAseq Workflow 5. Differential responses to BRAFi treatment in CSF 6. RNAseq shows CSF from Patient 4 to elicit transcriptional modulation of melanoma cell response to BRAF inhibition 7. CSF from LMM patients elicits transcriptional changes in melanoma cells 8. CSF protects melanoma cells from BRAF inhibitor therapy 9. CSF activates AKT in WM164 10. No-LMM CSF does not induce expression of TGFbeta or activation of AKT 11. ELISA assay showing the levels of TGFβ1 in CSF specimens from extrordi- nary responder (Patient 1) and non-responders.
Language: English
Topic: Melanoma and MAPK Pathways
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361969647