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Supplemental Figure 3 from Toxicity Attribution in Phase I Trials: Evaluating the Effect of Dose on the Frequency of Related and Unrelated Toxicities

Year: 2023

Type: supplementary-materials

Abstract: Demonstrates hypothetically the effect that systematic misattribution of disease-related toxicities as drug-related could have on the observed rate of drug-related toxicity as well as its relationship with dose. In this example, the observed rate of drug-related toxicity increases by 10% across all dose levels but the relationship with dose (as demonstrated by the slope of the curve) remains unchanged.

DOI: 10.1158/1078-0432.22461639

Authors: Anne Eaton, Alexia Iasonos, Mrinal M. Gounder, Erika G. Pamer, Alexander Drilon, Diana Vulih, Gary L. Smith, S. Percy Ivy, David R. Spriggs, David M. Hyman

Language: English

Topic: Statistical Methods in Clinical Trials

Subfield: Statistics and Probability

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361969949

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