Work

Supplemental Figure 1 from SRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer

Year: 2023

Type: supplementary-materials

Abstract: (A) Representative examples of marker response by IHC for CHGA, SYP, and AR in CRPC bone metastases. 05-114: CHGA+/SYP+/AR-, 05-221: CHGA+/SYP+/AR- (white arrow), CHGA-/SYP-AR+ (black arrow). 07-042: CHGA+/SYP+AR+. Percent of (B) CHGA and (C) SYP positive cells in 22 CRPC CHGA+/SYP+ metastases. Virtually all cells in CHGA+/SYP+ metastases had a neuroendocrine phenotype.

DOI: 10.1158/1078-0432.22461824

Authors: Xiaotun Zhang, Ilsa M. Coleman, Lisha G. Brown, Lawrence D. True, Lori Kollath, Jared M. Lucas, Hung-Ming Lam, Ruth Dumpit, Eva Corey, Lisly Chéry, Bryce Lakely, Celestia S. Higano, Bruce Montgomery, Martine Roudier, Paul H. Lange, Peter S. Nelson, Robert L. Vessella, Colm Morrissey

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4361970954

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