Supplemental Figures from CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1–Dependent IGF-1 Signaling
Year: 2023
Type: supplementary-materials
Abstract: Fig. S1. Expression of CRM1 in EWS cell lines. Fig. S2. Treatment of KPT-330 caused tolerable cytotoxic effect in normal CD34+ cells. Fig. S3.p53 is regulated to drive KPT-330 dependent anti-proliferation effect in wildtype EWS cell lines. Fig. S4. KPT-330 has modest effect on regulation of other fusion proteins. Fig. S5. Combination of KPT-330 and Crizotinib synergistically inhibited cell proliferation in EWS cell lines. Fig. S6. Venn diagram of genes co-downregulated by KPT-330 compared with genes downregulated by EWS-FLI1.
Authors: Haibo Sun, De-Chen Lin, Qi Cao, Xiao Guo, Helene Marijon, Zhiqiang Zhao, Sigal Gery, Liang Xu, Henry Yang, Brendan Pang, Victor Kwan Min Lee, Huey Jin Lim, Ngan Doan, Jonathan W. Said, Peiguo Chu, Anand Mayakonda, Tom Thomas, Charles Forscher, Erkan Baloglu, Sharon Shacham, Raja Rajalingam, H. Phillip Koeffler
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4361850403