Supplementary Tables 1 though 7 from Balancing Protein Stability and Activity in Cancer: A New Approach for Identifying Driver Mutations Affecting CBL Ubiquitin Ligase Activation
Year: 2023
Type: supplementary-materials
Abstract: Table S1. Classification of mutations and definition of different classes. Table S2. P-values for different null hypotheses calculated by two-sample t-test. Table S3. Top 25% cancer mutations with the largest energy changes for each state in CBL activation cycle. Table S4. Binding free energy for wild-type CBL-E2-S and pCBL-E2-S states. Table S5. Pearson correlation coefficients (R) between experimental densitometry values and predicted changes in stability and binding affinity. Table S6. True positive rates are listed corresponding to different false positive rates. Table S7. Experimental relative densitometry values for HEK293T cell line, predicted changes in stability, binding affinity and comparison with other methods for 15 experimentally tested mutations.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361973753