Supplementary Figures 1 though 6 from Balancing Protein Stability and Activity in Cancer: A New Approach for Identifying Driver Mutations Affecting CBL Ubiquitin Ligase Activation
Year: 2023
Type: supplementary-materials
Abstract: Fig. S1. The distribution of unfolding and binding free energy changes for Single, Recurrent and Random class mutations for all states in CBL activation cycle. Fig.S2. The distribution of local RMSD of mutant structures for Single, Recurrent and Random class mutations for CBL-E2-S and pCBL-E2-S states. Fig. S3. Mean values and standard errors of local RMSD of mutant structures for different classes of mutations for CBL-E2-S and pCBL-E2-S states, respectively. Fig. S4. The number of "Single" and "Recurrent" mutations located on CBL-E2 interface, non-interface and interior regions in inactive CBL-E2-S and active pCBL-E2-S structures. Fig. S5. Structures of wild type and K382E mutant for all states. Fig. S6. EGFR ubiquitination by Cbl mutants that retain wild-type activity in A549 and Hela cells.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4361973894