Work

Activity-dependent constraints on catecholamine signaling

Year: 2023

Type: article

Abstract: Catecholamine signaling is thought to modulate cognition in an inverted-U relationship, but the mechanisms are unclear. We measured norepinephrine and dopamine release, postsynaptic calcium responses, and interactions between tonic and phasic firing modes under various stimuli and conditions. High tonic activity in vivo depleted catecholamine stores, desensitized postsynaptic responses, and decreased phasic transmission. Together, these findings provide a more complete understanding of the inverted-U relationship, offering insights into psychiatric disorders and neurodegenerative diseases with impaired catecholamine signaling.

Source: Cell Reports

DOI: 10.1016/j.celrep.2023.113566

Authors: Li Li, Akshay N. Rana, Esther M. Li, Jiesi Feng, Yulong Li, Michael R. Bruchas